top of page

Senior Scientist/Principal Scientist, Pharmacology

Cambridge, MA   ·   Full-time

Reports To: Sr. Director and Head of Clinical Pharmacology

Company Overview:

METiS Therapeutics Inc is a biotechnology company with a unique technology platform that has the potential to drive best-in class drug assets in a wide range of therapeutic areas. Through the integration of machine learning, quantum simulation, and high-throughput experimentation, we enable scientists to rapidly, comprehensively, and intelligently develop novel drug candidates. METiS is founded by an enthusiastic team of MIT researchers and serial entrepreneurs. Our cross-disciplinary expertise and deep industry experiences allow METiS to harness AI to boldly deliver revolutionary therapies for patients with serious diseases.



We are seeking a highly skilled, motivated, and collaborative Sr. Scientist/Principal Scientist to join our Pharmacology team. In this position, you will play a critical role to support our internal drug discovery programs in diverse therapeutic areas and to evaluate external asset acquisition/collaboration opportunities by closely working with our Chemistry, Business Development and AI teams. You will be responsible for in vitro assay development/implementation and in vivo proof-of-concept studies (internally or at CROs) to enable small molecule screening efforts. This is a very exciting opportunity for a scientist who would like to thrive in a dynamic, high-energy and collaborative cross-disciplinary team in a rapidly growing company.


  • Serve as a pharmacology representative and the subject matter expert for multiple drug discovery programs 

  • Critically evaluate drug targets selected by our AI and/or BD teams and explore novel therapeutic hypotheses for expansion of our internal programs and external collaboration opportunities 

  • Design, execute and interpret in vitro and in vivo studies (either in-house or at CROs) to screen small molecule drug candidates, identify/validate PD biomarkers and establish PK/PD relationships  

  • Identify and manage CROs/academic sites in the conduct of in vitro/in vivo studies and oversee study executions 

  • Participate in discussion with KOLs and due diligence for in-licensing opportunities and  

  • Think strategically about drug development and drive innovative solutions to key challenges across the organization

Minimum Qualifications:

  • PhD in Biology, Pharmacology, Translational Science or a related field  

  • Minimum 5 years of industry experience  

  • Experience managing studies conducted at CROs  

  • Strong communication skills, presentation skills and cross-functional collaboration are required  

  • Experience in Microsoft suite (Word, PowerPoint, Excel etc.), GraphPad Prism and other relevant software is required

Preferred Qualifications:

  • Experience in immunology, nephrology, and/or oncology preferred 

  • Experience successfully preparing Pharmacology sections of regulatory documents is a plus

RECRUITING & STAFFING AGENCIES: METiS Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to METiS or its employees is strictly prohibited unless contacted directly by METiS recruiting team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of METiS, and METiS will not owe any referral or other fees with respect thereto.

bottom of page